WP lead Dr Tina Gaarder, Oslo
Partner 4 will lead the consortium in the set-up and conduct of a prospective, exploratory randomized control trial comparing the effect of patient-matched haemostatic resuscitation, using VHA treatment algorithmversus local empiric treatment. Specific objectives here are to:
- Assess the potential clinical efficacy in correction of TIC upon outcomes.
- Define potential resource use, costs and cost-effectiveness of adopting VHA-led therapy.
- Assess the performance of risk stratification model in identifying coagulopathic patients and preventing unnecessary transfusion.
- Provide data for the external validation of TACTIC study outputs.
Development of study protocol.
With Partner 5 as sponsor, the RCT will be conducted by Partners 1-5 and the John Radcliffe Hospital, Oxford, UK as third party beneficiary to Partner 1 and coordinated by Partner 5.
Prospective enrolment of trauma patients.
Data capture, analysis & reporting.
Health economic analysis.