WP lead Dr Nicole Juffermans, Amsterdam
The aim is to demonstrate how the administration of specified amounts of blood products and pro-coagulants influence haemostatic competence within different patterns of TIC patients. This will enable the development of a personalized treatment algorithm for the correction of functional coagulation in coagulopathic patients . Partner 2 will lead this WP to:
- Define functional and molecular changes due to therapy, based on output from WP4&5.
- Deliver a patient-matched treatment algorithm for the different coagulopathic patterns.
Describe molecular response to existing pro-coagulation therapy.
Determine functional coagulation response to existing therapy.
Deliver personalised treatment algorithm for the targeted correction of coagulopathy.